Payton's work during his internship at the University of Nebraska-Lincoln led to a role in a rehab hospital that included responsibilities within management and as a clinical dietitian within long-term care. After several years in the traditional healthcare approach, Payton felt like he could be doing more for people in a different setting. Payton became very interested in the idea of metabolic health and preventative health and began researching, which eventually led him to Nutrisense.